Wednesday, January 27, 2010

Pathopyhsiology of ARDS

Most common cause of ARDS is sepsis.

Direct lung injury may cause ARDS or ARDS may develop as a consequence of the systemic inflammatory response syndrome or multiple organ dysfunction syndrome.

An exact cause for the damage to the alveolar-capillary membrane is not known.
The pathophysiological changes of ARDS are thought to be due to stimulation of the inflammatory and immune systems which causes an attraction of neutrophils to the pulmonary interstitium. The neutrophils cause a release of biochemical, humoral and cellular mediators that produce changes in the lung.

The pathophysiological changes in ARDS are divided into three phases:
1. Injury or Exudative Phase
2. Reparative or Proliferative Phase
3. Fibrotic Phase

(Lewis, et. al 2007 pg 1812- 1813)

2 comments:

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